Which cell type is most associated with chronic inflammation leading to tissue remodeling?

Which cell type is most associated with chronic inflammation leading to tissue remodeling?

• A. Neutrophils
• B. Fibroblasts
• C. Macrophages
• D. Lymphocytes

Answer: (B)

Chronic inflammation that leads to tissue remodeling is driven by fibroblasts. These cells lay down and reorganize the extracellular matrix, producing collagen and other matrix components that form scar tissue and fibrotic changes. They can differentiate into myofibroblasts to contract tissue and pull the wound tight, facilitating remodeling over time. Neutrophils are mainly involved in acute inflammation and short‑lived; macrophages and lymphocytes are present in chronic inflammation and regulate the response, but the actual remodeling of tissue structure is carried out by fibroblasts.

Chronic inflammation that leads to tissue remodeling is driven by fibroblasts. These cells lay down and reorganize the extracellular matrix, producing collagen and other matrix components that form scar tissue and fibrotic changes. They can differentiate into myofibroblasts to contract tissue and pull the wound tight, facilitating remodeling over time. Neutrophils are mainly involved in acute inflammation and short‑lived; macrophages and lymphocytes are present in chronic inflammation and regulate the response, but the actual remodeling of tissue structure is carried out by fibroblasts.